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Allergic rhinitis

Highlights

Allergic Rhinitis

Allergic rhinitis is the way some people respond to outdoor or indoor allergens:

  • Outdoor triggers of allergic rhinitis include ragweed, grass, tree pollen, and mold spores, Outdoor allergens cause seasonal allergic rhinitis (also known as hay fever), which typically occurs during the spring and summer.
  • Indoor triggers include dust mites, pet dander, or mold that grows in humid indoor places such as carpets. Indoor allergens can cause perennial (year-round) allergic rhinitis.

Allergic rhinitis tends to run in families. If one or both parents have allergic rhinitis, there is a high likelihood that their children will also have allergic rhinitis. People with allergic rhinitis have an increased risk of developing asthma and other allergies. They are also at risk for developing sinusitis, sleep disorders (including snoring), nasal polyps, and ear infections.

Symptoms

Common symptoms of allergic rhinitis include:

  • Runny nose or nasal congestion
  • Frequent sneezing
  • Itchy watery eyes
  • Itching in nose, throat, or roof of mouth

Treatment

Home remedies for allergic rhinitis include nasal washes with a saline solution. Many different over-the-counter and prescription drugs are used to treat allergic rhinitis. These medications include oral and nasal antihistamines, corticosteroid nasal sprays, cromolyn, leukotriene antagonists such as montelukast (Singulair), and decongestants. Many of these drugs have side effects. Immunotherapy (“allergy shots”) may also be an option for some patients.

Prevention

In addition to avoiding exposure to allergy triggers, people with allergic rhinitis can take precautions to control their environment. These measures include bathing pets weekly, using vacuum cleaners and air conditioners with high efficiency particulate air (HEPA) filters, frequent washing of bedding and curtains, reducing humidity in the house, and removing sources of mold.

Drug Approval

In 2013, the FDA approved a liquid form of antihistamine for treatment of seasonal and perennial allergic rhinitis. Carboxamine (Karbinal ER) is approved for patients ages 2 years and older.

Introduction

Rhinitis is inflammation of the mucous membrane of the nasal passages. It results from severe nasal congestion or other changes that irritate the nose.

Allergic rhinitis is caused by a substance (allergan) that triggers an allergic response. As part of the allergic response, the body’s immune system launches a defensive attack by releasing histamine and other chemicals.

Allergic rhinitis is generally classified as either:

  • Seasonal (also called hay fever)
  • Perennial (year-round)

Allergens involved in allergic rhinitis come from either outdoor or indoor substances:

  • Outdoor allergens such as pollen or mold spores are usually the cause of seasonal allergic rhinitis.
  • Indoor allergens such as animal dander or dust mites are common triggers of perennial allergic rhinitis.

Rhinitis can also be due to non-allergic causes such as infections, temperature changes, hormonal changes, certain medications, cigarette smoke, stress, exercise, structural problems in the nose, or other factors. In non-allergic rhinitis, the immune system does not play a role in the body’s response to these factors.

Basic symptoms of both allergic and non-allergic rhinitis include:

  • Runny nose
  • Nasal congestion
  • Nasal itching
  • Sneezing
  • Watery eyes
Allergic rhinitis

 Click the icon to see an image of allergic rhinitis.   

Causes

The allergic process, called atopy, occurs when the body overreacts to a substance that it senses as a foreign “invader". The immune system works continuously to protect the body from potentially dangerous intruders such as bacteria, viruses, and toxins. However, for reasons not completely understood, some people are hypersensitive to substances that are typically harmless.

When the immune system inaccurately identifies these substances (allergens) as harmful, an allergic reaction and inflammatory response occurs.

  • When an allergen enters the body, the immune system produces immunoglobulin E (IgE) antibodies. These IgE antibodies then attach themselves to mast cells, which are found in the nose, eyes, lungs, and digestive tract.
  • The mast cells release inflammatory chemical mediators, such as histamine, that cause atopic symptoms (sneezing, coughing, wheezing). The mast cells continue to produce more inflammatory chemicals that stimulate the production of more IgE antibodies, continuing the allergic process.

There are many types of IgE antibodies, and each are associated with a specific allergen. This is why some people are allergic to cat dander, while others are not bothered by cats yet are allergic to pollen. In allergic rhinitis, the allergic reaction begins when an allergen comes into contact with the mucous membranes in the lining of the nose.

Triggers of Seasonal Allergic Rhinitis (Hay Fever)

Seasonal allergic rhinitis occurs only during periods of intense airborne pollen or spores. It is commonly, although inaccurately, called hay fever. No fever accompanies this condition, and the allergic response is not dependent on hay. In general, triggers of seasonal allergy in the U.S. include:

  • Ragweed. Ragweed is the main cause of allergic rhinitis in the United States. Ragweed season generally lasts from mid-August through the first frost. One plant can release 1 billion pollen grains during the course of a season. Pollen counts are usually highest between 10am – 3pm.
  • Grasses. Grass pollen, especially from ryegrass, is another common cause of allergic rhinitis. Grasses affect people from late spring to early summer. Grass allergies are experienced more in the late afternoon.
  • Tree Pollen. Small pollen grains from certain trees usually produce symptoms in the early spring.
  • Mold Spores. Mold spores grow on dead leaves and release spores into the air. They peak in the spring in warmer climates and in the fall in cooler climates. In some warmer parts of the United States, they may be prevalent year round.
Allergies

 Click the icon to see an animation about hay fever. 

Triggers of Perennial (Year-Round) Allergic Rhinitis

Allergens in the House. Allergens in the home are the most common triggers of perennial (year-round) allergic rhinitis. Household allergens include:

  • House dust and mites. Dust mites, specifically mite feces, are coated with enzymes that contain a powerful allergen.
  • Cockroaches
  • Pet dander
  • Molds growing on wallpaper, house plants, carpeting, and upholstery

Risk Factors

Age

Allergic rhinitis usually first appears in childhood or early adulthood but it can affect people of all ages.

Family History

Allergic rhinitis appears to have a genetic component. People with a parent who has allergic rhinitis have an increased risk of developing allergic rhinitis themselves. The risk increases significantly if both parents have allergic rhinitis.

Environmental Exposure

Home or workplace environments can increase the risk for exposure to allergens (mold spores, dust mites, and animal dander) associated with allergic rhinitis.

Breastfeeding

Exclusively breastfeeding for the first 4 months of life appears to help prevent or delay allergies in high-risk infants. It is not clear if breastfeeding helps prevent the development of allergic rhinitis. There is some evidence that breastfeeding may help prevent wheezing and other symptoms of asthma, a condition that is sometimes associated with allergic rhinitis.

Prognosis

Seasonal allergic rhinitis tends to diminish as a person ages. The earlier the symptoms start, the greater the chances for improvement. People who develop seasonal allergic rhinitis in early childhood tend not to have the allergy in adulthood. In some cases, allergies go into remission for years and then return later in life. People who develop allergies after age 20, however, tend to continue to have allergic rhinitis at least into middle age.

Complications

Asthma and Other Allergies

Asthma and allergies often coexist. Patients with allergic rhinitis often have asthma or are at increased risk of developing it. Allergic rhinitis is also associated with eczema (atopic dermatitis), an allergic skin reaction characterized by itching, scaling, and red swollen skin. Chronic uncontrolled allergic rhinitis can worsen asthma attacks and eczema.

Quality of Life

Although allergic rhinitis is not considered a serious condition, it can interfere with many important aspects of life. Nasal allergy sufferers often feel tired, miserable, or irritable. Allergic rhinitis can interfere with work or school performance.

People with allergic rhinitis, particularly those with perennial allergic rhinitis, may experience sleep disorders and daytime fatigue. Often they attribute this to allergy medication, but congestion may be the cause of these symptoms. Patients who have severe allergic rhinitis tend to have worse sleep problems, including snoring, than those with mild allergic rhinitis.

Chronic Swelling in the Nasal Passages (Turbinate Hypertrophy)

Any chronic rhinitis, whether allergic or nonallergic, can cause swelling in the turbinates, which may become persistent (turbinate hypertrophy). The turbinates are tiny shelf-like bony structures that project into the nasal passageways. They help warm, humidify, and clean the air that passes over them. If turbinate hypertrophy develops, it causes persistent nasal congestion and, sometimes, pressure and headache in the middle of the face and forehead. This condition may require surgery.

Other Complications

Other possible complications of allergic rhinitis include:

  • Sinusitis
  • Middle ear infections (otitis media)
  • Nasal polyps
  • Sleep apnea
  • Dental overbite
  • Palate malformations caused by mouth breathing

Symptoms

Symptom Phases

Symptoms of allergic rhinitis often occur in two phases, early and late.

Early Phase Symptoms. The early phase occurs within minutes of exposure to the allergens and includes:

  • Runny nose
  • Frequent or repetitive sneezing
  • Watery or itchy eyes
  • Itching in the nose, throat, or roof of the mouth

Late-Phase Symptoms. Symptoms that may develop several hours or later include:

  • Nasal congestion. This is a common symptom in children. Children may push their nose upward with the palm of their hand or twitch their nose rabbit-like to clear the obstruction.
  • Plugged ears
  • Poor sleep and fatigue, which can lead to irritability and difficulty concentrating
  • Eye sensitivity to light. In severe allergies, dark circles may develop under the eye. The lower eyelid may be puffy and lined with creases.
  • Postnasal drip
  • Sinus headache
  • Decreased sense of smell or taste

Symptom Classification

A newer classification system groups allergic rhinitis by how long symptoms last and how severe they are:

  • Intermittent rhinitis occurs less than 4 days a week and for less than 4 weeks per year
  • Persistant rhinitis occurs at least 4 days during a week and for at least 4 weeks in the year
  • Mild rhinitis causes minimal symptoms that do not impact sleep and daily life
  • Moderate-to-severe rhinitis has symptoms that cause enough discomfort to affect day-to-day, work, or school activities as well as to disrupt sleep

Diagnosis

In most cases, a doctor can diagnose allergic rhinitis based on the patient's symptoms. Your doctor will take your medical history and will ask about:

  • When your rhinitis occurs. Rhinitis that appears seasonally is typically due to pollens and outdoor allergens. If symptoms occur throughout the year, the doctor will suspect perennial allergic or non-allergic rhinitis.
  • Exposure to household or occupational allergans, including pets.
  • Personal history of asthma or other allergies.
  • Any family history of allergies.

Physical Examination

The doctor may examine the inside of the nose with an instrument called a speculum. This is a painless procedure that allows the doctor to check for redness and other signs of inflammation. The doctor will also usually check the eyes, ears, and chest.

Allergy Skin Tests

Allergy testing may be used to confirm an allergic trigger identified by symptoms. A skin test is a simple method for detecting common allergens. Patients are usually tested for a panel of common allergens. Skin tests are rarely needed to diagnose milder seasonal allergic symptoms before a trial of treatment. Skin tests are not  completely accurate and are not appropriate for children younger than age 3.

The procedure is as follows:

  • Patients should not take antihistamines for at least 12 - 72 hours before the test. Otherwise an allergic reaction may not show up.
  • Small amounts of suspected allergens are applied to the skin with a needle prick or scratch or are injected a few cells deep into the skin. The injection test may be more sensitive than the standard prick test.
  • If an allergy is present, a hive (a swollen reddened area) forms within about 20 minutes.

In most situations, before testing occurs patients would have tried to avoid any of their known allergens, as well as tried medications, including nasal corticosteroid sprays. However, patients with more severe symptoms, particularly those with asthma, significant eczema, or nasal polyps, may benefit from earlier skin testing.

Laboratory Tests

Nasal Smear. The doctor may take a nasal smear. The nasal secretion is examined microscopically for factors that might indicate a cause, such as increased numbers of white blood cells, indicating infection, or high counts of eosinophils. High eosinophil counts indicate an allergic condition, but low counts do not rule out allergic rhinitis.

Tests for IgE. Blood tests for IgE immunoglobulin production may also be performed. Newer enzyme-based assays using IgE antibodies have replaced an older test called RAST (radioallergosorbent test). The tests detect increased levels of allergen-specific IgE in response to particular allergens. Blood tests for IgE may be less accurate than skin tests. They should be performed only on patients who cannot undergo skin testing or when skin test results are uncertain.

Nasal Endoscopy

In some cases of chronic or unresponsive seasonal rhinitis, a doctor may use endoscopy to examine for any irregularities in the nose structure. Endoscopy uses a tube inserted through the nose that contains a miniature camera to view the passageways.

Ruling Out Other Conditions

Rhinitis always precedes and accompanies sinusitis, which is inflammation or infection of the mucosal lining of the sinuses. Acute sinusitis usually clears up on its own. Chronic sinusitis can be more difficult to treat.

Allergic rhinitis also needs to be distinguished from the cold or flu:

  • Allergic rhinitis symptoms begin right after exposure to an allergen. Colds or flu develop several days after exposure to a virus.
  • Allergic rhinitis symptoms last as long as you are exposed to the allergen. Cold and flu symptoms generally last 2 – 14 days.
  • The nasal discharge in allergic rhinitis is usually clear. In colds or flu it is yellow.
  • Colds and flu are often accompanied by aches and pain. A fever is a definite sign that the condition is a cold or flu and not allergic rhinitis.

Treatment

Patients with allergic rhinitis have many treatment options available to them:

  • Environmental control measures can help reduce exposure to allergens.
  • Nasal washes may provide good symptomatic relief for some patients.
  • Nasal medication sprays include nasal corticosteroid sprays, nasal antihistamine sprays, ipratopium bromide nasal spray, nasal cromolyn, and nasal decongestant sprays. DO NOT USE DECONGESTANT SPRAYS FOR MORE THAN THREE DAYS AT A TIME.
  • Antihistamine pills are available in many brands by prescription and over-the-counter. Some are combined with decongestants. Decongestant pills may also be used by themselves.
  • Other anti-inflammatory drugs may be used, including leukotriene antagonists.
  • Immunotherapy ("allergy shots") are another option.

All drug treatments have side effects, some very unpleasant and, in rare cases, serious. Patients may need to try different drugs until they find one that relieves symptoms without producing excessively distressing side effects.

Treatment of Mild Allergic Rhinitis

Treating mild allergy attacks usually involves little more than reducing exposure to allergens and using a nasal wash. Medications may also be used. Most medications for mild allergic rhinitis are available without a prescription.

Treatments for mild allergic rhinitis include:

  • Nasal washes
  • Decongestants that relieve nasal congestion and itchy eyes for children over the age of 2 and adults
  • Second-generation, non-sedating antihistamines such as cetirizine (Zyrtec, generic), loratadine (Claritin, generic), fexofenadine (Allegra, generic), or desloratadine (Clarinex). These medications cause less drowsiness than older antihistamines such as diphenhydramine (Benadryl, generic). They are also available as decongestant/antihistamine combinations.

Treatment of Moderate-to-Severe Allergic Rhinitis

For people who suffer from moderate-to-several seasonal allergies, doctors recommend:

  • Prescription drugs are required only in severe cases. Because seasonal allergies generally last only a few weeks, most doctors do not recommend the stronger prescription treatments for children. However, in children with both asthma and allergies, treatments for allergic rhinitis may also improve asthma symptoms.
  • Patients with severe seasonal allergies should start medications a few weeks before the pollen season and continue taking them until the season is over.
  • Immunotherapy ("allergy shots") may be an option for patients with severe seasonal allergies that do not respond to other treatments.

Patients with perennial (year-round) allergic rhinitis or those who have bothersome symptoms that are active during most of the year may require daily medications. This is especially true if patients also have asthma.

Drug treatments for moderate-to-severe allergic rhinitis include

  • Anti-inflammatory drugs. Nasal corticosteroids are recommended for patients with moderate-to-severe allergies, either alone or in combination with second-generation antihistamines.
  • Antihistamines. The second-generation, non-sedating antihistamines -- such as cetirizine (Zyrtec, generic), loratadine (Claritin, generic), fexofenadine (Allegra, generic), or desloratadine (Clarinex) -- cause less drowsiness than older antihistamines, such as diphenhydramine (Benadryl, generic). They are recommended alone or in combination with nasal corticosteroids for treatment of moderate-to-severe allergic rhinitis. Nasal antihistamine sprays also work well.
  • Leukotriene-antagonists and nasal cromolyn may be beneficial in specific cases.
  • Immunotherapy ("allergy shots") works well for many patients with severe allergies who do not respond to other treatments. It can also help reduce asthma symptoms and the use of asthma medications in patients with known allergies.

Nasal Washes

For mild allergic rhinitis, a nasal wash can help remove mucus from the nose. You can purchase a saline solution at a drug store or make one at home (2 cups of warm water, a teaspoon salt, pinch of baking soda). If you prepare your own saline solution, use bottled or boiled water, not plain tap water.

Here is a simple method for administering a nasal wash:

  • Lean over the sink head down.
  • Pour some solution into the palm of the hand and inhale it through the nose, one nostril at a time.
  • Spit the remaining solution out.
  • Gently blow the nose.

Neti pots have also become popular in recent years for prevention and treatment of allergic rhinitis. Nasal irrigation with a saline solution through a neti pot involves:

  • Lean over the sink with your head tilted to one side.
  • Insert the spout of the neti pot in the upper nostril.
  • Slowly pour the salt water into your nose while continuing to breathe through your mouth.
  • The water will flow through the upper nostril and out through the lower nostril.
  • When the water finishes dripping out, blow your nose.
  • Reverse the tilt of your head and repeat the process with the other nostril.

Treating Itchy Eyes

Antihistamine pills can sometimes help itching and redness in the eyes. Eye drops provide faster relief, and a combination of the two may be best. Eye drops for itchy eyes include.

  • Antihistamine eye drops: azelastine (Optivar, generic), olopatadine (Patanol), ketotifen (Zaditor, generic), levocabastine (Livostin) for relief of both nasal symptoms and itchy red eyes
  • Decongestant eye drops: naphazoline (Naphcon, , generic), tetrahydrozoline (Visine, Tyzine, generic)
  • Combination decongestant/antihistamine: Visine-A, Opcon-A
  • Corticosteroids: loteprednol (Lotemax, Alrex), pemirolast (Alamast)
  • Non-steroidal antiinflammatory eye drops: ketorolac (Acular, generic)

General Side Effects and Warnings.

  • All eye drops can cause stinging, and some may result in headache and nasal congestion.
  • No one should continue taking eye drops if they experience pain, changes in vision, worsened redness, or irritation, or if the condition lasts more than 3 days.
  • Do not touch the tip of the device to the eye or touch other surfaces with it. Replace the cap after using. Discard any solution that changes color or becomes cloudy.
  • People who have heart disease, high blood pressure, an enlarged prostate gland, or glaucoma should talk to their doctor before taking these types of eye drops.

Other Treatments (Alternative and Complementary Medicine)

Some patients with allergies report symptom relief through modalities such as acupuncture and Chinese herbal medicine. While some studies have reported symptom improvement, it is not clear if this is due to a placebo effect.

Medications

Antihistamines

Histamine is one of the chemicals released when antibodies overreact to allergens. It is the cause of many symptoms of allergic rhinitis. Antihistamine drugs can help relieve:

  • Itching, sneezing, and runny nose (unless combined with a decongestant, antihistamines do not work well for relieving nasal congestion).
  • Other allergy symptoms unrelated to rhinitis, including hives and some rashes

If possible, take an antihistamine before an anticipated allergy attack.

Many antihistamines are available. They include short-acting and long-acting forms, and come in oral pill and nasal spray forms.

Antihistamines are generally categorized as first- and second-generation. First-generation antihistamines, which include diphenhydramine (Benadryl, generic) and clemastine (Tavist, generic) cause more side effects (such as drowsiness) than most newer second-generation antihistamines. For this reason, second-generation antihistamines are generally preferred and recommended over first-generation antihistamines.

There are some notes of caution when taking any antihistamine:

  • Antihistamines may thicken mucus secretions and can worsen bacterial rhinitis or sinusitis.
  • Antihistamines can lose their effectiveness over time and a different one may need to be tried.

Second-generation antihistamines are sometimes referred to collectively as nonsedating antihistamines. However, cetirizine (Zyrtec, generic) and the nasal spray antihistamines (Astelin, Patanase) may cause drowsiness when taken at recommended doses. Loratidine (Claritin, generic) and desloratadine (Clarinex) can cause drowsiness when taken at doses exceeding the recommended dose.

Brand Names. Second-generation antihistamines in pill form include:

  • Loratadine (Claritin, generic). Loratadine is available over-the-counter and is approved for children ages 2 and older. Loratine-D (Claritin-D) combines the antihistamine with the decongestant pseudoephedrine. Desloratadine (Clarinex) is similar to Claritin but stronger and longer-lasting. It is available only by prescription.
  • Cetirizine (Zyrtec, generic). Cetirizine is approved for both indoor and outdoor allergies. It is the only antihistamine to date approved for infants as young as 6 months. It is available over-the-counter. Cetirizine-D (Zyrtec-D) is a pill that combines the antihistamine with the decongestant pseudoephedrine.
  • Fexofenadine (Allegra, generic) is also available over-the-counter.
  • Levocetirizine (Xyzal) is a prescription medication approved to treat seasonal allergic rhinitis in patients age 2 years and older. It is available in both pill and liquid form.
  • Acrivastine and pseudoephedrine (Semprex-D) is a pill that combines an antihistamine and decongestant.

Second-generation antihistamines in nasal form are as good as or better than the oral forms for treatment of seasonal allergic rhinitis. However, they can cause drowsiness, and are not as effective for allergic rhinitis as nasal corticosteroids. Nasal spray antihistamines are available by prescription and include:

  • Azelastine (Astelin, Astepro, Dymista)
  • Oloptadine (Patanase)

In 2013, the FDA approved a liquid form of antihistamine for treatment of seasonal and perennial allergic rhinitis. Carboxamine (Karbinal ER) is approved for patients age 2 years and older.

Side Effects and Precautions.

  • Common side effects include headache, dry mouth, and dry nose. (These are often only temporary and go away during treatment.)
  • Drowsiness may occur. The nasal spray forms of second-generation antihistamines cause more drowsiness than the pill forms.
  • Extended-release forms of loratadine and cetirizine have other ingredients that can cause other symptoms, including nervousness, restlessness, and insomnia.

Nasal Corticosteroids

Corticosteroids help reduce the inflammatory response associated with allergic reactions. Nasal-spray corticosteroids (commonly called steroids) are considered the most effective drugs for controlling the symptoms of moderate-to-severe allergic rhinitis. They are often used either alone or in combination with second-generation oral antihistamines.

The benefits of nasal spray steroids include:

  • Reducing inflammation and mucus production
  • Improving night sleep and daytime alertness in patients with chronic allergic rhinitis
  • Treating polyps in the nasal passages

Nasal-Spray Brands. Corticosteroids available in nasal spray form include:

  • Triamcinolone (Nasacort, generic). Approved for patients age 2 and older.
  • Mometasone furoate (Nasonex). Approved of patients age 3 and older.
  • Fluticasone (Flonase, generic). Approved for patients age 2 and older.
  • Fluticasone and azelastine (Dymista). Approved for patients age 12 and older.
  • Beclomethasone (Beconase, Vancenase, generic). Approved for patients age 6 and older.
  • Flunisolide (Nasarel, generic). Approved for patients age 6 and older.
  • Budesonide (Rhinocort, generic). Approved for patients age 6 and older.
  • Ciclesonide (Alvesco, Omnaris). Approved for patients age 12 and older

Side Effects. Corticosteroids are powerful anti-inflammatory drugs. Although oral steroids can have many side effects, the nasal-spray form affects only local areas and has less risk for widespread side effects unless the drug is used excessively. Side effects of nasal steroids may include:

  • Dryness, burning, stinging in the nasal passage
  • Sneezing
  • Headaches and nosebleed (uncommon but should be reported to your doctor immediately)

Possible Long-Term Complications. All corticosteroids suppress stress hormones. This effect can produce some serious long-term complications in people who take oral steroids. Researchers have found far fewer concerns with nasal administration or inhaled forms, but there may be certain problems:

  • Effect on growth. The major concern for children is whether nasal steroids, like other forms of steroids, will adversely affect growth. Research indicates that most children who only take recommended dosages of nasal sprays, and do not also take inhaled corticosteroids for asthma, will not have any problems.
  • Effect on eyes. Glaucoma is a known side effect of oral steroids. Studies to date have not shown that nasal steroids increase risk for glaucoma. Still, patients should have periodic eye exams.
  • Use during pregnancy. Steroids are most likely safe during pregnancy but if you are pregnant talk to your doctor before taking them.
  • Nasal passage injury. Steroid sprays may injure the nasal septum (the bony area that separates the nasal passage) if the spray is directed onto it. This complication is very rare.
  • Lower resistance to infection. People with any infectious disease or injury in the nose should not take these drugs until the disease or wound has been treated and cured.

Cromolyn

Cromolyn serves as both an anti-inflammatory drug and a specific blocker for allergens. The standard cromolyn nasal spray (Nasalcrom, generic) is not as effective as steroid nasal sprays but does work well for many people with mild allergies. It is one of the preferred first-line therapies for pregnant women with mild allergic rhinitis. It may take up to 3 weeks to experience full benefit.

Side Effects. Cromolyn has no major side effects, but minor ones include nasal congestion, coughing, sneezing, wheezing, nausea, nosebleeds, and dry throat. The spray can cause burning or irritation.

Leukotriene Antagonists

Leukotriene antagonists are oral drugs that block leukotrienes, powerful immune system factors that cause airway constriction and mucus production in allergy-related asthma. They appear to work as well as antihistamines for treatment of allergic rhinitis, but are not as effective as nasal corticosteroids.

Leukotriene antagonists include zafirlukast (Accolate) and montelukast (Singulair). These drugs are mainly used to treat asthma. Montelukast is also approved to treat seasonal allergies and indoor allergies.

The FDA warns that these drugs have been associated with behavior and mood changes, including agitation, aggression, anxiousness, dream abnormalities, hallucinations, depression, insomnia, irritability, restlessness, tremor, and suicidal thinking and behavior. Patients who take a leukotriene antagonist drug such as montelukast should be monitored for signs of behavioral and mood changes. Doctors should consider discontinuing the drug if patients exhibit any of these symptoms.

Decongestants

Decongestants work by shrinking blood vessels in the nose. Many over-the-counter decongestants are available, which can be either taken by mouth or applied to the nose.

Nasal Decongestants. Nasal-delivery decongestants are applied directly into the nasal passages with a spray, gel, drops, or vapors. Nasal decongestants come in long-acting or short-acting forms. The effects of short-acting decongestants last about 4 hours. Long-acting decongestants last 6 - 12 hours. The active ingredients in nasal decongestants include oxymetazoline, xylometazoline, and phenylephrine. Nasal forms work faster than oral decongestants and may not cause as much drowsiness. However, they can cause dependency and rebound.

The major problem with nasal-delivery decongestants, particularly long-acting forms, is a cycle of dependency and rebound effects. The 12-hour brands pose a particular risk for this effect.

  • With prolonged use (more than 3 - 5 days), nasal decongestants lose effectiveness and can cause swelling in the nasal passages.
  • The patient then increases the frequency of the dose. As the congestion worsens, the patient may respond with even more frequent doses.
  • This causes dependency and increased nasal congestion.

The following precautions are important for people taking nasal decongestants:

  • When using a nasal spray, spray each nostril once. Wait a minute to allow absorption into the mucosal tissues, and then spray again.
  • Do not share droppers and inhalers with other people.
  • Discard sprayers, inhalers, or other decongestant delivery devices when the medication is no longer needed. Over time, these devices can become reservoirs for bacteria.
  • Discard the medicine if it becomes cloudy or unclear.
  • DO NOT USE NASAL DECONGESTANTS FOR LONGER THAN THREE DAYS.

Oral Decongestants. Oral decongestants also come in many brands, which have similar ingredients. The most common active ingredients are pseudoephedrine (Sudafed, other brands, generic) and phenylephrine, sometimes in combination with an antihistamine. Oral decongestants can cause side effects such as insomnia, irritability, nervousness, and heart palpitations. Taking pseudoephedrine in the morning, as opposed to later in the day or before bedtime, can help patients avoid these side effects.

Individuals at Risk for Complications from Decongestants. People who may be at higher risk for complications are those with certain medical conditions, including disorders that make blood vessels highly susceptible to contraction. Such conditions include:

  • Heart disease
  • High blood pressure
  • Thyroid disease
  • Diabetes
  • Prostate problems that cause urinary difficulties
  • Migraines
  • Raynaud's phenomenon
  • High sensitivity to cold
  • Chronic obstructive pulmonary disorder (COPD). People with emphysema or chronic bronchitis should avoid high-potency, short-acting nasal decongestants.

No one with these conditions should use oral or nasal decongestants without a doctor's guidance. Other people who should not use decongestants without first consulting a doctor include:

  • Pregnant women
  • Children. Children metabolize decongestants differently than adults. Decongestants should not be used at all in infants and children under the age of 4 years, and some doctors recommend not giving them to children under the age of 14. Children are at particular risk for central nervous system side effects, including convulsions, rapid heart rates, loss of consciousness, and death.

Decongestants can cause dangerous interactions when combined with certain types of medications, such as the antidepressant MAO inhibitors. They can also serious problems when combined with methamphetamines or diet pills. Be sure to tell your doctor about any drug or herbal remedy you are taking. Caffeine can also increase the stimulant side effects of pseudoephedrine.

Nasal Ipratropium

Ipratropium bromide (Atrovent, generic) is a prescription nasal spray that can help relieve runny nose. It works best when given in combination with a nasal corticosteroid. Side effects include nasal dryness, nosebleeds, and sore throat. It should not be used by people who have glaucoma or men who have an enlarged prostate gland.

Immunotherapy

Immunotherapy (commonly called "allergy shots") is a safe and effective treatment for patients with allergies. It is based on the premise that people who receive injections of a specific allergen will lose sensitivity to that allergen. The most common allergens for which shots are given are house dust, cat dander, grass pollen, and mold.

Immunotherapy benefits include:

  • Targeting the specific allergen
  • Reducing sensitivity in airways in the lungs as well as in the upper airways
  • Preventing the development of new allergies in children
  • Reducing asthma symptoms and the use of asthma medications in patients with known allergies. Research suggests it may also help prevent the development of asthma in children with allergies.

Candidates

Candidates for Immunotherapy. Immunotherapy may be given to anyone with allergies that do not get better with medication and who has had a positive allergy test to specific allergens. The latest guidelines indicate that immunotherapy is safe for young children. Immunotherapy is safe for pregnant women who are already receiving it, although half-strength doses are generally recommended, and it should not be started during pregnancy.

Individuals at Risk for Complications. People who should probably avoid immunotherapy include those who have:

  • An extreme response to skin tests (this may predict an allergic reaction).
  • Wheezing.
  • Uncontrolled severe asthma or lung disease.
  • Patients taking certain medications (such as beta blockers).
  • The health status of anyone should be determined before starting treatment.

Administering Therapy

The major downside to immunotherapy is that it requires a prolonged course of weekly injections. The process generally includes:

  • Injections of diluted extracts of the allergen are given on a regular schedule, usually twice a week to weekly at first, then in increasing doses until a maintenance dose has been reached. It usually takes several months and may take up to 3 years to reach a maintenance dose.
  • At that time, intervals between shots can be 2 - 4 weeks, and the treatment is continued for another 3 - 5 years.
  • Patients can experience some relief within 3 - 6 months. If there is no benefit within 12 - 18 months, discontinue the shots.
  • Injections are usually administered subcutaneously into the skin of the arm.

The use of an injection series is effective, but patients often have difficulty complying with the regimens. Some other schedules and delivery methods are being investigated that might make the program easier:

  • Rush Immunotherapy uses several shots a day over a period of 3 - 5 days to achieve the full dose. Studies suggest that it is effective and safe, but anaphylaxis and severe reactions can occur. Patients must be selected carefully and must be monitored closely during this period for severe reactions.
  • Sublingual Immunotherapy is an oral form of immunotherapy that uses an under-the-tongue tablet. Although sublingual immunotherapy is prescribed in many countries in Europe and South America, it is not approved in the United States.

Recent reviews indicate that sublingual therapy may be helpful for asthma in particular, and may also be beneficial for allergic rhinitis and rhinoconjunctivitis. However, many questions remain including dosage and duration of treatment. At this time, sublingual immunotherapy is not considered standard practice in the United States. Other studies indicate that subcutaneous immunotherapy is more effective than sublingual immunotherapy.

Side Effects and Complications of Immunotherapy

Injections for ragweed and, sometimes, dust mites have higher risks for side effects than other allergy shots. If complications or allergic reactions develop, they usually occur within 20 minutes, although some can develop up to 2 hours after the shot is given.

Side effects of immunotherapy include:

  • General itching, swelling, red eyes, hives, soreness at the injection site.
  • Less common side effects are low blood pressure, asthma worsening, or difficulty breathing. This is due to an extreme hypersensitivity response called anaphylaxis. It can also occur if excessive doses are given.
  • In rare cases, particularly because of excessive doses or if a patient has a serious lung problem, severe reactions can occur, which can be life threatening.
  • Pre-medicating patients with antihistamines and corticosteroids may help reduce the risk of reactions to immunotherapy, although this could mask early warning signs.

Lifestyle Changes

People with existing allergies should avoid irritants or allergens. These triggers include:

  • Pollen. This is the primary cause of allergic rhinitis.
  • Dust mites, specifically mite feces, which are coated with enzymes that contain a powerful allergen. These are the primary allergens inside the home.
  • Animal dander (flakes of skin) and hair from cats, house mice, and dogs. House mice are a significant source of allergens, particularly in urban children.
  • Molds.
  • Fungi.
  • Cockroaches are major asthma triggers and may reduce lung function even in people without a history of asthma.

Some studies suggest that early exposure to some of these allergens, including dust mites and pets, may actually prevent allergies from developing in children.

Indoor Protection against Allergens

Controlling Pets. People who already have pets and are not allergic to them are probably at low risk for developing such allergies later on. When children are exposed to more than one dog or cat during their first year, they have a much lower risk for not only pet allergies but also seasonal allergies and asthma. (Pet exposure does not protect them from other allergens, notably dust mites and cockroaches).

For children who have an existing allergy to pets:

  • If possible, pets should be given away or kept outside.
  • If this isn't possible, they should at least be confined to carpet-free areas outside the bedroom. Cats harbor significant allergens, which can even be carried on clothing. Dogs usually present fewer problems.
  • Washing animals once a week can reduce allergens. Dry shampoos, such as Allerpet, that remove allergens from skin and fur and are available for both cats and dogs and are easier to use than wet shampoos.

Preventing Exposure to Cigarette and Cooking Smoke. Although cigarette smoke is not a trigger for allergic rhinitis, parents who smoke should quit. Studies show that exposure to second-hand smoke in the home increases the risk for asthma and asthma-related emergency room visits in children.

Controlling Dust. Spray furniture polish is very effective for reducing both dust and allergens. Air cleaners, filters for air conditioners, and vacuum cleaners with High Efficiency Particulate Air (HEPA) filters can help remove particles and small allergens found indoors. Neither vacuuming nor the use of anti-mite carpet shampoo is, however, effective in removing mites in house dust. Vacuuming actually stirs up both mites and cat allergens. People with these types of allergies should avoid having carpets or rugs in their homes. For children with allergies, vacuuming should be performed when the child is not around.

Bedding and Curtains:

  • Replace curtains with shades or blinds, and wash bedding using the highest temperature setting.
  • Encase mattress and pillows in special dust mite proof covers (however, washing is very important since impermeable covers alone do not help prevent allergies and studies have not proven benefit with these covers).
  • Wash pillows in water hotter than 150 °F, or in cooler water with detergent and bleach.
  • Wash sheets and blankets weekly in hot water.
  • Avoid sleeping or lying on cushions or furniture that is cloth covered.
  • Stuffed toys should be kept away from the bed and washed weekly as described above. Placing toys in a dryer or freezer may help but is not considered enough protection.
  • Children should sleep as high off the floor as possible (avoid the bottom bunk of a bunk bed).

Reducing Humidity in the House. Living in a damp environment is counterproductive:

  • Humidity levels should not exceed 30 - 50%.
  • Fix all leaky faucets and pipes, and eliminate collections of water around the outside of the house.
  • Dehumidify basements, but empty and clean humidifier daily with a vinegar solution.
  • Clean often any moldy surfaces in basement or in other areas of the home.

Exterminating Pests (Cockroaches and Mice):

  • Use professional exterminators to eliminate cockroaches. (Cleaning the house using standard housecleaning techniques may not eliminate the cockroach allergens themselves.)
  • Exterminate mice and attempt to remove all dust, which might contain mouse urine and dander.
  • Keep food and garbage in closed containers.
  • Keep food out of bedrooms.

Outdoor Protection

Avoiding Outdoor Allergens. The following are some recommendations for avoiding allergens outside:

  • Start taking allergy medications 1 - 2 weeks before ragweed season begins. Be sure to take allergy medications before going outside. If regular medications do not work, ask your doctor about allergy shots.
  • Camping and hiking trips should not be scheduled during times of high pollen count (May and June for grass pollen and September to October for ragweed).
  • Patients who are allergic should avoid barns, hay, raking leaves, and mowing grass. (A mask can be worn during outdoor chores to help reduce pollen exposure.)
  • Sunglasses can help prevent pollen from getting into eyes.
  • After being outdoors, clean off pollen residue by bathing, washing hair and clothes, and using a nasal salt water rinse.
  • Keep doors and windows closed during pollen season.

Dietary Factors

Some evidence suggests that people with allergic rhinitis and asthma may benefit from a diet rich in omega-3 fatty acids (found in fish, almonds, walnuts, pumpkin, and flax seeds) and fruits and vegetables (at least five servings a day). Researchers are also studying probiotics -- so-called good bacteria, such as lactobacillus and bifidobacterium-- which can be obtained in supplements. Some studies have found that probiotics may help reduce allergic rhinitis symptom severity and medication use.

Resources

References

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Review Date: 6/24/2013
Reviewed By: Harvey Simon, MD, Associate Professor of Medicine, Harvard Medical School; Physician, Massachusetts General Hospital. Also reviewed by David Zieve, MD, MHA, Medical Director, A.D.A.M., Inc.
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